Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet

Phytotherapy for the correction of excess body weight is widely used. However, a comprehensive study herbal preparations on organism model animals has been carried out only few plant species. Supplementing diet rats with closely related sage species (Salvia officinalis L. and S. sclarea L.) against background high-fat hypercaloric triggered multidirectional changes in their metabolism. The addition crushed dry shoots to led sharp increase (up 130.8% initial one 30 days experiment). treated increased up 103.8% was lower than control group. Addition caused an daily gain 253.1% group, – its decrease 27.8% In relative brain, spleen, thymus decreased, while decreased that colon increased. Under influence officinalis, concentration urea, total bilirubin, triglycerides blood plasma male protein activity alkaline phosphatase While consuming shoots, there rats’ blood, but atherogenic index (23.1% level group) sharply dropped due high-density lipoprotein cholesterol (286.9% control) low-density (67.7% control). feeding we observed (39.9% control), gamma-glutamyl transferase (62.8%), Ca/P ratio (132.5% group). No significant were CBC WBC differential when eating shoots. According results open field test, physical orientational under significantly by end experiment. Emotional status rats, contrary, they ate composition food. Thus, conditions more pronounced deviations from norm officinalis. animals’ normalized comparison reduced negative manifestations obesity at biochemical organismal levels. this regard, substances contains should be carefully studied anti-atherosclerotic activity, tea supplemented can recommended as corrective supplement overweight people.